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Pain and Migraine Headache

The neurobiology of migraine headache and accompanying episodes of sensory disturbance is poorly understood and no diagnositc biomarker has yet been identified. Our team conducts clinical studies on migraine, chronic pain and neuroinflammation as well as research on valid pain models.

The neurobiology of migraine headaches and accompanying sensory disturbances is not fully understood, and a diagnostic biomarker has yet to be identified. In the study group, clinical studies related to migraine, chronic pain, and neuroinflammation are being conducted, alongside research on valid pain models.

Clinical neurophysiological studies focused on issues such as sensory integration and sensorimotor integration problems in migraine patients, mechanisms of multiple sensory disorders, and temporal differentiation of somatosensory, visual, and auditory sensory modalities are ongoing. Clinical and translational studies related to the gut-brain axis are being conducted by examining gut permeability, inflammatory biomarkers, and microbiome profiles in migraine and medication overuse headache.

Current experimental headache models investigate mechanisms such as cortical spreading depression, nitroglycerin and levcromacalim induced sensory perception through thalamic gating, modulation of the somatosensory cortex, and triggers of headache caused by food, medication, etc.

These scientific studies are supported by projects like BAP, ADEP, TÜBİTAK 1004, TCSBB, and TÜBA.

IHS 1-1

2-1

1-1

H B-1

Prof. Dr. Hayrunnisa Bolay Belen

Doğa Vurallı-1

Dr. Öğr. Üyesi Doğa Vurallı

Yıldırım SARA-1

Prof. Dr. Mehmet Yıldırım SARA

Ergin Dileköz-1

Doç. Dr. Ergin DİLEKÖZ

Merve Akgör-1

Uzm. Dr. Merve Hilal Ceren Akgör

Dr. Hale Gök Dağıdır

Merve Sevgi İnce-1

Öğr. Gör. Merve Sevgi İnce Güzel

elif-1

Öğr. Gör. Elif Gülçiçek Abbasoğlu Topa

Berkay-1

Berkay ALPAY

Alumni and Previous Team Members

Dr. Didem AKÇALI

Dr. Özgür AKDEMİR

Dr. Merve AKGÖR

Dr. Çile AKTAN

Dr. Arzu ARAL

Dr. Ahmet BAŞARI

Dr. Evren BORAN

Dr. Fırat BÜYÜKTAŞKIN

Dr. Hacer DOĞANAY

Dr. Aslı FİLİZ

Dr. Elif KELEŞ

Dr. Serap ERDOĞAN TAYCAN

Dr. Nermin TEPE

Dr. Tuğçe TOPTAN

Dr. Doğa VURALLI

Dr. Duygu KAYA YERTUTANOL

Dr. Fünuzar YILDIRIM

Yayın 2-1

Distinct Food Triggers for Migraine, Medication Overuse Headache and Irritable Bowel Syndrome

Akgor M. C., Vuralli D., Sucu D. H., Gokce S., Tasdelen B., Gultekin F., et al.

JOURNAL OF CLINICAL MEDICINE , cilt.12, sa.20, ss.1-15, 2023 (SCI-Expanded)

yayın 3-1

Levcromakalim provokes an acute rapid-onset migraine-like phenotype without inducing cortical spreading depolarization

Alpay B., Cimen B., Akaydin E., Bolay H. B., Sara Y.

The journal of headache and pain , cilt.24, sa.1, ss.93, 2023 (SCI-Expanded)

Evaluation of Auditory Temporal Discrimination Thresholds in Migraine Patients

Gokdogan O., Gokdogan C., Yalcinkaya F., Cengiz B., Bolay H. B.

Audiology & neuro-otology , ss.1-7, 2023 (SCI-Expanded)

Visual temporal discrimination is impaired in patients with migraine without aura

Başarı A., Boran H. E., Vuralli D., Cengiz B., Bolay H. B.

Headache , cilt.63, sa.2, ss.202-210, 2023 (SCI-Expanded)

Headache attributed to SARS-CoV-2 infection, vaccination and the impact on primary headache disorders of the COVID-19 pandemic: A comprehensive review

Caronna E., Van Den Hoek T. C., Bolay H. B., Garcia-Azorin D., Gago-Veiga A. B., Valeriani M., et al.

Cephalalgia : an international journal of headache , cilt.43, sa.1, 2023 (SCI-Expanded)

Handbook of Animal Models in Neurological Disorders-1

Handbook of Animal Models in Neurological Disorders

Animal Models of Headache

Doğa vurallı, Hayrunnisa Bolay

ISBN :978-0-323-89833-1

Academic Press

https://doi.org/10.1016/C2020-0-02387-X

Migraine susceptibility is modulated by food triggers and analgesic overuse via sulfotransferase inhibition

Vuralli D., Arslan B., Topa E. G., De Morais A. L., Gulbahar Ö., Ayata C., et al.

JOURNAL OF HEADACHE AND PAIN , cilt.23, sa.1, 2022 (SCI-Expanded)

das-1

Interrupted processing of paired somatosensory stimuli in short interstimulus intervals: role of thalamo-cortical oscillations

Tepe N., Boran H. E., Geduk S., Dileköz E., Ulusoy İ., Belen H. B.

TURKISH JOURNAL OF MEDICAL SCIENCES , cilt.52, sa.4, ss.1371-1377, 2022 (SCI-Expanded)

HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanism

Bolay H. B., Karadas Ö., Oztürk B., Sonkaya R., Tasdelen B., Bulut T. D. S., et al.

JOURNAL OF HEADACHE AND PAIN , cilt.22, sa.1, 2021 (SCI-Expanded)

Latent class cluster analysis identified hidden headache phenotypes in COVID-19: impact of pulmonary infiltration and IL-6

Karadaş Ö., Öztürk B., Sonkaya A. R., Taşdelen B., Özge A., Bolay H. B.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology , cilt.42, ss.1665-1673, 2021 (SCI-Expanded)