Başak Ceyda Meço (Doç. Dr)
meco@ankara.edu.tr
Molecular Neurogenetics and Neurophysiology
Disorders that include schizophrenia, autism spectrum disorders, attention deficit hyperactivit disorder, specific learning disabilities and intellectual disability constitute one of the leading health problems worldwide with disease burden and economic loss according to World Health Organization data.
Neurodevelopmental disorders, in which a large number of genetic and environmental factors play a role in their emergence, are a group of diseases that face great difficulties due to the fact that their mechanisms have not been fully elucidated, there are no objective biomarkers to be used in diagnosis and/or follow up, effective treatment is available for very few of them, and drug development processes are slow and expensive. The most effective approach to overcome these problems caused by neurodevelopmental disorders is to increase our basic knowledge about how these disorders occur.
The main research focus of our laboratory is to elucidate the molecular etiology of neurodevelopmental disorders with the “from genes to cognitive functions” approach. In this context, our research on:
-The identification of novel candidate (epi)genetic alterations associated with neurodevelopmental disorders
-Revealing the genotype-phenotype relationships of known/newly identified (epi)genetic alterations by performing detailed clinical phenotyping from a multidisciplinary perspective
-The establishment of disease cell models to elucidate the functional significance of these changes
-Investigating (epi)genetic factors associated with higher cognitive functions continues.
GÜMÜŞ AKAY LAB
Prof. Dr. Güvem Gümüş Akay
ggumusakay@ankara.edu.tr
Filiz Çetinkaya (Doktora Öğr)
filizogan@gmail.com
Mezunlar:
Burcu ÇEVİK, MSc
Yayınlar
Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study
Fusar-Poli, L., Pries, L. K., van Os, J., Erzin, G., Delespaul, P., Kenis, G., Luykx, J. J., Lin, B. D., Richards, A. L., Akdede, B., Binbay, T., Altınyazar, V., Yalınçetin, B., Gümüş-Akay, G.,et al.
Prog Neuropsychopharmacol Biol Psychiatry. 2021;110440.
Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study
Erzin G, Pries LK, van Os J, Fusar-Poli L, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Eur Psychiatry. 2021;64(1):e25
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings
Velthorst E, Mollon J, Murray RM, de Haan L, Germeys IM, Glahn DC, Arango C, van der Ven E, Di Forti M, Bernardo M, Guloksuz S, Delespaul P, Mezquida G, Amoretti S, Bobes J, Saiz PA, García-Portilla MP, Santos JL, Jiménez-López E, Sanjuan J, Aguilar EJ, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Atbaşoğlu C, Saka MC, Üçok A, Alptekin K, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G, et al.
Mol Psychiatry. 2021;10.1038/s41380-020-00969-z
Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum
Pries LK, Dal Ferro GA, van Os J, Delespaul P, Kenis G, Lin BD, Luykx JJ, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Epidemiol Psychiatr Sci. 2020;29:e182
Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway
van Os J, Pries LK, Ten Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin BD, Luykx JJ, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Psychol Med. 2020;1-13
A replication study of JTC bias, genetic liability for psychosis and delusional ideation
Henquet C, van Os J, Pries LK, Rauschenberg C, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Psychol Med. 2020;1-7
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling
Frega M, Linda K, Keller JM, Gümüş-Akay G, et al.
Nat Commun. 2019;10(1):4928
White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?
Schepers E, Lousberg R, Guloksuz S, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Front Psychiatry. 2019;10:676
Pries LK, Lage-Castellanos A, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altinyazar V, Yalinçetin B, Gümüş-Akay G, et al.
Schizophr Bull. 2019;45(5):960-965
Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study
van Os J, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Psychol Med. 2020;50(11):1884-1897
Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study
Guloksuz S, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
World Psychiatry. 2019;18(2):173-182
Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls
Çevik B, Mançe-Çalışır Ö, Atbaşoğlu EC, Saka MC, Alptekin K, Üçok A, Sırmatel B, Gülöksüz S, Tükün A, van Os J, Gümüş-Akay G.
J Psychiatr Res. 2019;111:169-185
E-posta: aubeyinarastirmalari@gmail.com, duygubandirmali@gmail.com
Telefon: (312) 595 8272
Adres: Ankara Üniversitesi Tıp Fakültesi Morfoloji Kampüsü
Dekanlık Binası Fizyoloji Anabilim Dalı
Sıhhiye/Ankara
Last Updated : 6.03.2024