Başak Ceyda Meço (Assoc. Prof)
meco@ankara.edu.tr
Neurodevelopmental Disorders
These disorders, which include schizophrenia, autism spectrum disorders, attention deficit and hyperactivity disorder, specific learning difficulties and intellectual disability, constitute one of the leading health problems worldwide in terms of disease burden and economic loss, according to the data of the World Health Organization. Neurodevelopmental disorders are a group of diseases that are faced with great difficulties in which many genetic and environmental factors play a role, are due to reasons such as not fully elucidating their mechanisms, lack of objective biomarkers to be used in the diagnosis and/or follow-up, effective treatment for very few, and slow and expensive drug development processes. The most effective approach in dealing with these problems caused by neurodevelopmental disorders is to increase the basic knowledge we have about how these disorders arise.
The main research focus of our laboratory is to elucidate the molecular etiologies of neurodevelopmental disorders with the "from genes to cognitive functions" approach.
In this context, we are continuing our research on these issues;
- Detection of new candidate (epi)genetic changes associated with neurodevelopmental disorders
- Revealing the genotype-phenotype relationships of known/newly defined (epi)genetic changes with a multidisciplinary perspective and detailed clinical phenotyping
- Establishment of disease cell models to elucidate the functional significance of these changes
- Examination of (epi)genetic factors associated with higher cognitive functions.
GÜMÜŞ AKAY LAB
Prof. Dr. Güvem Gümüş Akay
ggumusakay@ankara.edu.tr
Filiz Çetinkaya (PhD Student)
filizogan@gmail.com
Duygu Bandırmalı (Master Student)
duygubandirmali@gmail.com
Former Lab Members:
Burcu ÇEVİK, MSc
Publications
Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study
Fusar-Poli, L., Pries, L. K., van Os, J., Erzin, G., Delespaul, P., Kenis, G., Luykx, J. J., Lin, B. D., Richards, A. L., Akdede, B., Binbay, T., Altınyazar, V., Yalınçetin, B., Gümüş-Akay, G.,et al.
Prog Neuropsychopharmacol Biol Psychiatry. 2021;110440.
Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study
Erzin G, Pries LK, van Os J, Fusar-Poli L, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Eur Psychiatry. 2021;64(1):e25
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings
Velthorst E, Mollon J, Murray RM, de Haan L, Germeys IM, Glahn DC, Arango C, van der Ven E, Di Forti M, Bernardo M, Guloksuz S, Delespaul P, Mezquida G, Amoretti S, Bobes J, Saiz PA, García-Portilla MP, Santos JL, Jiménez-López E, Sanjuan J, Aguilar EJ, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Atbaşoğlu C, Saka MC, Üçok A, Alptekin K, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G, et al.
Mol Psychiatry. 2021;10.1038/s41380-020-00969-z
Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum
Pries LK, Dal Ferro GA, van Os J, Delespaul P, Kenis G, Lin BD, Luykx JJ, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Epidemiol Psychiatr Sci. 2020;29:e182
Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway
van Os J, Pries LK, Ten Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin BD, Luykx JJ, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Psychol Med. 2020;1-13
A replication study of JTC bias, genetic liability for psychosis and delusional ideation
Henquet C, van Os J, Pries LK, Rauschenberg C, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Psychol Med. 2020;1-7
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling
Frega M, Linda K, Keller JM, Gümüş-Akay G, et al.
Nat Commun. 2019;10(1):4928
White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?
Schepers E, Lousberg R, Guloksuz S, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Front Psychiatry. 2019;10:676
Pries LK, Lage-Castellanos A, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altinyazar V, Yalinçetin B, Gümüş-Akay G, et al.
Schizophr Bull. 2019;45(5):960-965
Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study
van Os J, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Psychol Med. 2020;50(11):1884-1897
Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study
Guloksuz S, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
World Psychiatry. 2019;18(2):173-182
Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls
Çevik B, Mançe-Çalışır Ö, Atbaşoğlu EC, Saka MC, Alptekin K, Üçok A, Sırmatel B, Gülöksüz S, Tükün A, van Os J, Gümüş-Akay G.
J Psychiatr Res. 2019;111:169-185
E-mail: aubeyinarastirmalari@gmail.com, duygubandirmali@gmail.com
Phone: (312) 595 8272
Adress: Ankara University Faculty of Medicine,
Department of Physiology,
Sıhhiye/Ankara
Last Updated : 3.11.2022