Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations.

European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI); van Os J, Rutten BP, Myin-Germeys I, Delespaul P, Viechtbauer W, van Zelst C, Bruggeman R, Reininghaus U, Morgan C, Murray RM, Di Forti M, McGuire P, Valmaggia LR, Kempton MJ, Gayer-Anderson C, Hubbard K, Beards S, Stilo SA, Onyejiaka A, Bourque F, Modinos G, Tognin S, Calem M, O'Donovan MC, Owen MJ, Holmans P, Williams N, Craddock N, Richards A, Humphreys I, Meyer-Lindenberg A, Leweke FM, Tost H, Akdeniz C, Rohleder C, Bumb JM, Schwarz E, Alptekin K, Üçok A, Saka MC, Atbaşoğlu EC, Gülöksüz S, Gumus-Akay G et al.

Schizophr Bull. 2014 Jul;40(4):729-36. doi: 10.1093/schbul/sbu069. Epub 2014 May 24.PMID: 24860087

Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia.

Durmaz CD, Karabulut HG, Saka MC, Sucularlı C, Gümüş Akay G, Atbaşoğlu C, Ilgın Ruhi H.

Balkan Med J. 2022 Nov 7;39(6):422-428. doi: 10.4274/balkanmedj.galenos.2022.2022-5-90. Epub 2022 Oct 28.PMID: 36305088

A replication study of JTC bias, genetic liability for psychosis and delusional ideation.

Henquet C, van Os J, Pries LK, Rauschenberg C, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G et al.

Psychol Med. 2022 Jul;52(9):1777-1783. doi: 10.1017/S0033291720003578. Epub 2020 Oct 13.PMID: 33046166 

Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study.

Fusar-Poli L, Pries LK, van Os J, Erzin G, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G et al.

Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110440. doi: 10.1016/j.pnpbp.2021.110440. Epub 2021 Sep 16.PMID: 34536513

Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.

Fusar-Poli L, Prachason T, Erzin G, Pries LK, Brondino N, Politi P, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G et al.

Psychiatry Res. 2023 May;323:115184. doi: 10.1016/j.psychres.2023.115184. Epub 2023 Mar 28.

PMID: 37015164

Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway.

van Os J, Pries LK, Ten Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin BD, Luykx JJ, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G et al.

Psychol Med. 2022 Jul;52(10):1910-1922. doi: 10.1017/S0033291720003748. Epub 2020 Oct 19. PMID: 33070791

Görev: araştırmacı

Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.

Frega M, Linda K, Keller JM, Gümüş-Akay G, Mossink B, van Rhijn JR, Negwer M, Klein Gunnewiek T, Foreman K, Kompier N, Schoenmaker C, van den Akker W, van der Werf I, Oudakker A, Zhou H, Kleefstra T, Schubert D, van Bokhoven H, Nadif Kasri N.

Nat Commun. 2019 Oct 30;10(1):4928. doi: 10.1038/s41467-019-12947-3.PMID: 31666522

Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation

van der Meer D., Cheng W., Rokicki J., Fernandez-Cabello S., Shadrin A., Smeland O. B., et al.

Schizophrenia Bulletin , cilt.50, sa.2, ss.327-338, 2024 (SCI-Expanded, SSCI, Scopus)

Higher schizotypy predicts better metabolic profile in unaffected siblings of patients with schizophrenia.

Atbasoglu EC, Gumus-Akay G, Guloksuz S, Saka MC, Ucok A, Alptekin K, Gullu S, van Os J.

Psychopharmacology (Berl). 2018 Apr;235(4):1029-1039. doi: 10.1007/s00213-017-4818-z. Epub 2018 Jan 6.PMID: 29306964

The association between cannabis use and facial emotion recognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.

Fusar-Poli L, Pries LK, van Os J, Radhakrishnan R, Pençe AY, Erzin G, Delespaul P, Kenis G, Luykx JJ, Lin BD, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G et al.

Eur Neuropsychopharmacol. 2022 Oct;63:47-59. doi: 10.1016/j.euroneuro.2022.08.003. Epub 2022 Aug 30.PMID: 36055075

Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder.

Menteşe Babayiğit T, Gümüş-Akay G, Uytun MÇ, Doğan Ö, Serdar MA, Efendi GY, Erman AG, Yürümez E, Öztop DB.

Children (Basel). 2024 May 5;11(5):551. doi: 10.3390/children11050551.PMID: 38790546

Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings
Velthorst E, Mollon J, Murray RM, de Haan L, Germeys IM, Glahn DC, Arango C, van der Ven E, Di Forti M, Bernardo M, Guloksuz S, Delespaul P, Mezquida G, Amoretti S, Bobes J, Saiz PA, García-Portilla MP, Santos JL, Jiménez-López E, Sanjuan J, Aguilar EJ, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Atbaşoğlu C, Saka MC, Üçok A, Alptekin K, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G, et al.

Mol Psychiatry. 2021 Aug;26(8):4529-4543. doi: 10.1038/s41380-020-00969-z. Epub 2021 Jan 7. PMID: 33414498

White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?

Schepers E, Lousberg R, Guloksuz S, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G et al.

Front Psychiatry. 2019 Sep 25;10:676. doi: 10.3389/fpsyt.2019.00676. eCollection 2019.PMID: 31607966

Telomerase activity could be used as a marker for neoplastic transformation in gastric adenocarcinoma: but it does not have a prognostic significance.

Gümüş-Akay G, Unal AE, Bayar S, Karadayi K, Elhan AH, Sunguroĝlu A, Tükün A.

Genet Mol Res. 2007 Feb 15;6(1):41-9.PMID: 17469053

The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study.

Üçok A, Noyan H, Gülöksüz S, Saka MC, Alptekin K, Atbaşoğlu C, Akturan E, Karadayı G, Baran Tatar Z, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G et al.

Psychol Med. 2024 Jul;54(10):2414-2425. doi: 10.1017/S0033291724000540. Epub 2024 Apr 12.PMID: 38606591

Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.

Erzin G, Pries LK, van Os J, Fusar-Poli L, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G et al.

Eur Psychiatry. 2021 Mar 19;64(1):e25. doi: 10.1192/j.eurpsy.2021.19. PMID: 33736735

Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study.

Pries LK, Lage-Castellanos A, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altinyazar V, Yalinçetin B, Gümüş-Akay G et al.

Schizophr Bull. 2019 Sep 11;45(5):960-965. doi: 10.1093/schbul/sbz054.PMID: 31508804

Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls.

Çevik B, Mançe-Çalışır Ö, Atbaşoğlu EC, Saka MC, Alptekin K, Üçok A, Sırmatel B, Gülöksüz S, Tükün A, van Os J, Gümüş-Akay G.

J Psychiatr Res. 2019 Apr;111:169-185. doi: 10.1016/j.jpsychires.2019.01.022. Epub 2019 Feb 8.

PMID: 30776705

Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum.
Pries LK, Dal Ferro GA, van Os J, Delespaul P, Kenis G, Lin BD, Luykx JJ, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, et al.
Epidemiol Psychiatr Sci. 2020;29:e182. doi: 10.1017/S2045796020000943.PMID: 33200977